Effects on the maternofetal unit of the rabbit model after substitution of the amniotic fluid with perfluorocarbons

Objectives: Exchanging amniotic fluid (AF) with perfluorocarbon
(PFC) may serve as a medium for fetoscopic surgery. This study
evaluates the distribution and physiologic effects of intraamniotic
PFC as a medium for fetoscopy. Methods: Fetuses of 17 pregnant
rabbits underwent either exchange of the AF with PFC, electrolyte
solution (ES), or control. The quality of vision during fetoscopy
was assessed in AF and PFC. After 6 h, we determined the
distribution of PFC in the maternofetal unit. Results: Quality of
vision during fetoscopy was better in PFC than with AF. There was
no difference in fetal survival between the study groups. PFC was
demonstrated on X-ray in the pharynx of 4 fetuses, and the
esophagus in 1. Conclusions: PFC provided an ideal medium for
fetoscopy without fetal compromise. Copyright (c) 2005 S. Karger
AG, Basel.