Variants of the human PPARG locus and the susceptibility to chronic periodontitis

Apart from its regulatory function in lipid and glucose metabolism,
peroxisome proliferator-activated receptor (PPAR)γ has impact on
the regulation of inflammation and bone metabolism. The aim of the
study was to investigate the association of five polymorphisms
(rs10865710, rs2067819, rs3892175, rs1801282, rs3856806) within the
PPARG gene with chronic periodontitis. The study population
comprised 402 periodontitis patients and 793 healthy individuals.
Genotyping of the PPARG gene polymorphisms was performed by PCR and
melting curve analysis. Comparison of frequency distribution of
genotypes between individuals with periodontal disease and healthy
controls for the polymorphism rs3856806 showed a P-value of 0.04
but failed to reach significance after correction for multiple
testing (P  0.90). A 3-site analysis
(rs2067819-rs1801282-rs3856860) revealed five haplotypes with a
frequency of ≥1% among cases and controls. Following adjustment for
age, gender and smoking, none of the haplotypes was significantly
different between periodontitis and healthy controls after
Bonferroni correction. This study could not show a significant
association between PPARG gene variants and chronic periodontitis.