Random noise in Diffusion Tensor Imaging, its Destructive Impact and Some Corrections

The empirical origin of random noise is described, its influence on
DTI variables is illustrated by a review of numerical and in vivo
studies supplemented by new simulations investigating high noise
levels. A stochastic model of noise propagation is presented to
structure noise impact in DTI. Finally, basics of voxelwise and
spatial denoising procedures are presented. Recent denoising
procedures are reviewed and consequences of the stochastic model
for convenient denoising strategies are discussed.