Molecular cytotaxonomy of primates by chromosomal in situ suppression hybridization

A new strategy for analyzing chromosomal evolution in primates is
presented using chromosomal in situ suppression (CISS)
hybridization. Biotin-labeled DNA libraries from flow-sorted human
chromosomes are hybridized to chromosome preparations of
catarrhines, platyrrhines, and prosimians. By this approach
rearrangements of chromosomes that occurred during hominoid
evolution are visualized directly at the level of DNA sequences,
even in primate species with pronounced chromosomal shuffles.