Escalation of error catastrophe for enzymatic self-replicators
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vor 17 Jahren
It is a long-standing question in origin-of-life research whether
the information content of replicating molecules can be maintained
in the presence of replication errors. Extending standard
quasispecies models of non-enzymatic replication, we analyze highly
specific enzymatic self-replication mediated through an otherwise
neutral recognition region, which leads to frequency-dependent
replication rates. We find a significant reduction of the maximally
tolerable error rate, because the replication rate of the fittest
molecules decreases with the fraction of functional enzymes. Our
analysis is extended to hypercyclic couplings as an example for
catalytic networks.
the information content of replicating molecules can be maintained
in the presence of replication errors. Extending standard
quasispecies models of non-enzymatic replication, we analyze highly
specific enzymatic self-replication mediated through an otherwise
neutral recognition region, which leads to frequency-dependent
replication rates. We find a significant reduction of the maximally
tolerable error rate, because the replication rate of the fittest
molecules decreases with the fraction of functional enzymes. Our
analysis is extended to hypercyclic couplings as an example for
catalytic networks.
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