Noradrenaline release from permeabilized synaptosomes is inhibited by the light chain of tetanus toxin

Noradrenaline release from rat brain cortical synaptosomes
permeabilized with streptolysin O can be triggered by μM
concentrations of free Ca2+. This process was inhibited within
minutes by tetanus toxin and its isolated light chain, but not by
its heavy chain. The data demonstrate that the effect of tetanus
toxin on NA release from purified synaptosomes is caused by the
intraterminal action of its light chain.