Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa

Cyclophilin (cyclosporin A-binding protein) has a dual localization
in the mitochondria and in the cytosol of Neurospora crassa. The
two forms are encoded by a single gene which is transcribed into
mRNAs having different lengths and 5' termini (approximately 1 and
0.8 kilobases). The shorter mRNA specifies the cytosolic protein
consisting of 179 amino acids. The longer mRNA is translated into a
precursor polypeptide with an amino-terminal extension of 44 amino
acids which is cleaved in two steps upon entry into the
mitochondrial matrix. Neurospora cyclophilin shows about 60%
sequence homology to human and bovine cyclophilins.