Das multifokale Musterelektroretinogramm bei Patienten mit Glaukom und Neuritis Nervi Optici

Background: The multifocal pattern electroretinogram (mfPERG)
allows analysis of local ganglion cell dysfunction by multifocal
stimulation. Aim of this study was to investigate if this method is
an useful tool for diagnosing and following glaucoma patients.
Methods: Measurements on 52 age-matched normal eyes were compared
to those on 23 eyes with different stages of glaucoma. A RETIScan
system was used to generate a stimulus pattern of 19 hexagons, each
consisting of 6 triangles. The triangles pattern-reversed black to
white at 75 Hz. Those 19 hexagons form 3 stimulus regions: a
central field, a middle and a peripheral ring. The complete array
subtended 48° at the eye. The hexagons alternated black-white
following a corrected binary m-sequence (length 512, 10 cycles with
39 second each). Corneal loop electrodes were used with reference
electrode on temple. Results: The mfPERGs were analyzed for
significant changes in amplitude and latency of the positive and
negative responses. For patients with glaucoma the positive P-50
and negative N-95 components were significantly reduced for the
central area and both rings compared to normal volunteers
(p