Chemokine receptor CCR1: A new target for progressive kidney disease

Infiltrating leukocytes are thought to contribute to the
progression of kidney disease. Locally produced chemokines guide
circulating leukocytes into the kidney, which renders therapeutic
blockade of respective chemokine receptors on the leukocyte surface
as potential targets for the inhibition of renal leukocyte
recruitment. By using mutant mice and specific antagonists, we
found that chemokine receptor CCR1 has non-redundant functions for
leukocyte adhesion to activated vascular endothelium and for
transendothelial diapedesis. Most importantly, CCR1 blockade with a
specific small molecule antagonist can improve injury in several
types of progressive kidney disease models, even if treatment is
initiated in advanced disease states. Identification of new targets
may add to the therapeutic options in chronic kidney disease.
Copyright (C) 2005 S. Karger AG, Basel.