Use of long-term microdialysis subcutaneous glucose monitoring in the management of neonatal diabetes - A first case report

In neonatal diabetes mellitus (NDM), a rare genetic disorder,
insulin therapy is required but the management is difficult.
Frequent blood glucose determinations are necessary in most cases.
Microdialysis subcutaneous glucose monitoring (MSGM) is feasible in
neonates and has been proposed to reduce painful blood sampling and
blood loss. We have applied long-term MSGM to a small-fordate
female newborn with transient NDM. We found a good correlation of
subcutaneous and blood glucose concentration over a wide range of
values. MSGM enabled a reduction in blood glucose determinations
during optimization of intravenous insulin treatment and initiation
of continuous subcutaneous insulin infusion. We conclude that
long-term MSGM is feasible and may reduce painful blood sampling
and blood loss in NDM. Furthermore, long-term MSGM may hold a
potential for avoiding hypoglycemic episodes and earlier discharge.
Copyright (C) 2006 S. Karger AG, Basel.