The delay of contrast arrival in magnetic resonance first-pass perfusion imaging: a novel non-invasive parameter detecting collateral-dependent myocardium

Objectives: To establish the regional delay of contrast arrival in
magnetic resonance perfusion imaging (MRPI) for the detection of
collateral-dependent myocardium in patients with coronary artery
disease. Design and Setting: observational study, case series;
single center, university hospital. Patients: 30 patients with
coronary artery disease and collateral-dependent myocardium and 17
healthy volunteers. Methods: Resting and hyperemic (adenosine) MRPI
was used to determine delay time (Δtd) of contrast arrival between
the left ventricle and collateral-dependent or antegradely-perfused
myocardium, and myocardial perfusion (MP, ml/g/min). Results: In
healthy volunteers Δtd at rest and during hyperemia were 0.8±0.4
and 0.3±0.3 sec., and MP was 1.14±0.21 and 4.23±1.12 ml/min/g. Δtd
in antegradely-perfused vs. collateraldependent myocardium was
0.9±0.7 vs. 1.7±1.0 sec. at rest (p