Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization

We analyzed 19 chromophobe renal cell carcinomas by means of
comparative genomic hybridization. Two tumors revealed no numerical
abnormalities. In the remaining 17 cases we found loss of entire
chromosomes with underrepresentation of chromosome 1 occurring in
all 17 cases; loss of chromosomes 2, 10, and 13 in 16 cases; loss
of chromosomes 6 and 21 in 15 tumors; and loss of chromosome 17 in
13 cases. The loss of the Y chromosome was observed in 6 of 13
tumors from male patients, whereas 1 X chromosome was lost in 3 of
4 tumors obtained from females. Comparative genomic hybridization
results were verified by interphase cytogenetics. We conclude that
a specific combination of multiple chromosomal losses characterizes
chromophobe renal cell carcinomas and may help to differentiate
them unequivocally from other types of kidney cancer.