Hsp70 in mitochondrial biogenesis

The family of hsp70 (70 kilodalton heat shock protein) molecular
chaperones plays an essential and diverse role in cellular
physiology, Hsp70 proteins appear to elicit their effects by
interacting with polypeptides that present domains which exhibit
non-native conformations at distinct stages during their life in
the cell. In this paper we review work pertaining to the functions
of hsp70 proteins in chaperoning mitochondrial protein biogenesis.
Hsp70 proteins function in protein synthesis, protein translocation
across mitochondrial membranes, protein folding and finally the
delivery of misfolded proteins to proteolytic enzymes in the
mitochondrial matrix.