Studies towards total synthesis of polyketide natural products and alkaloids

Studies towards total synthesis of polyketide natural products and alkaloids

Beschreibung

vor 12 Jahren
Cascade reactions are powerful synthetic methods, which can be used
to introduce several C-C bonds and chiral centers in only one step.
This thesis deals with synthetic studies toward polyketide type I
and type II natural products as well as alkaloids, which are based
on cascade key steps. In the case of polyketide natural products
A-74528 and divergolides C and D, synthetic key steps inspired by
proposed biomimetic aldol and Michael cascade reactions were
approached. The work towards stephadiamine, a norhasubanan
alkaloid, was focused on the incorporation of homoconjugated
addition/Mannich cascade reaction. In addition, a radical
cyclization step, which is presumably incorporated in the
biogenesis of ansalactam A, was investigated.

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