Topical delivery of alpha1-Antichymotrypsin for wound healing

The work is introduced by reviews of wound healing and protein
delivery using hydrogel carriers. In the following, the formulation
studies of alpha1-Antichymotrypsin (ACT) are outlined starting with
solution carriers. The latter are followed by formulation studies
in hydrogels and dry gel forms, i.e. xerogels prepared by
freeze-drying and films gained from air drying of hydrogels. All
carriers are investigated upon their stabilizing activity on the
protein drug also for mid term shelf life, their suitability for
the use as wound dressings mainly from mechanical point of view,
and their release behaviour especially for ACT. As a result,
xerogel and film formulations are presented that match all
requirements for such a product.