Copper(I)-mediated anti-SN2’ Allylic Substitution Reactions with Diorganozinc Reagents

This work has been focused on the use of copper(I)-mediated
anti-SN2’ allylic substitution reactions with non directing leaving
groups. This proved to be a general and highly reliable method for
the preparation of new chiral stereogenic centers in high
enantioselectivity. Moreover a particular effort was made to apply
this method to more complex systems, and compounds like alcohols,
amines, alkenylsilanes or unsaturated nitriles could be
successfully prepared in their enantiomerically enriched form.