Gelatin Nanoparticles for Targeted Oligonucleotide Delivery to Kupffer Cells - Analytics, Formulation Development, Practical Application
Beschreibung
vor 17 Jahren
The present work follows a course of analytical description,
formulation development, and practical application of (NF-κB decoy
oligonucleotide-loaded) gelatin nanoparticles. The introduction of
asymmetrical flow field-flow fractionation (AF4) in the analysis of
colloidal drug carrier systems was exemplarily described for
gelatin nanoparticles (CHAPTER I), stable freeze-dried formulations
of empty and oligonucleotide loaded gelatin nanoparticles were
successfully developed (CHAPTER II), and gelatin nanoparticles were
proven as effective tool for the targeted delivery of an NF-κB
decoy oligonucleotide to Kupffer cells within a hepatic ischemia
reperfusion rat model (CHAPTER III).
formulation development, and practical application of (NF-κB decoy
oligonucleotide-loaded) gelatin nanoparticles. The introduction of
asymmetrical flow field-flow fractionation (AF4) in the analysis of
colloidal drug carrier systems was exemplarily described for
gelatin nanoparticles (CHAPTER I), stable freeze-dried formulations
of empty and oligonucleotide loaded gelatin nanoparticles were
successfully developed (CHAPTER II), and gelatin nanoparticles were
proven as effective tool for the targeted delivery of an NF-κB
decoy oligonucleotide to Kupffer cells within a hepatic ischemia
reperfusion rat model (CHAPTER III).
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vor 16 Jahren
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