The role of Src-homology 2 domain containing tyrosine phosphatase 2 in growth factor dependent endothelial signalling and angiogenesis
Beschreibung
vor 17 Jahren
Endothelial cell survival is indispensable to maintain endothelial
integrity and initiate new vessel formation. We investigated the
role of SHP-2 in proliferation, survival and sprouting of human
microvascular- and umbilical vein endothelial cells (HMEC, HUVEC)
using antisense oligonucleotides (AS-ODN) and a pharmacological
SHP-2 inhibitor (PtpI IV). Knock-down of SHP-2 decreased bFGF and
PDGF dependent endothelial cell proliferation (p
integrity and initiate new vessel formation. We investigated the
role of SHP-2 in proliferation, survival and sprouting of human
microvascular- and umbilical vein endothelial cells (HMEC, HUVEC)
using antisense oligonucleotides (AS-ODN) and a pharmacological
SHP-2 inhibitor (PtpI IV). Knock-down of SHP-2 decreased bFGF and
PDGF dependent endothelial cell proliferation (p
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vor 16 Jahren
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