Immunhistochemische Visualisierung von Cathepsin D und Glycodelin A am Mammakarzinom

121 breast cancer tumours were stained immunohistochemically with
Cath D mouse antibody and Gd A monoclonal mouse and polyklonal
rabbit antibody. For Cath D tumours with positive lymph nodes
showed significant higher expression as well as ductal carcinomas
compared to lobal carcinomas. For Gd A the monoclonal antibody
showed a positive correlation of staining with positive steroid
receptors (Estrogen and Progesteron). There was no association with
grading. The results fit into the concept of breakdown of
extracellular matrix by Cath D and its role in tumour progression
and metastasis as well as immunosuression an d the rolr in
tumourogenesis of Gd.