Intravitreal bevacizumab for the treatment of macular oedema secondary to branch retinal vein occlusion

Purpose: To evaluate the effect of intravitreal bevacizumab
(Avastin) injections on visual acuity (VA) and foveal retinal
thickness in patients with macular oedema secondary to branch
retinal vein occlusion.Methods: A prospective, non-comparative,
consecutive, interventional case series of 34 patients. Patients
received repeated intravitreal injections of 1.25 mg bevacizumab.
Main outcome measures were VA (Snellen charts and ETDRS) and
retinal thickness (optical coherence tomography measurements) in a
follow-up period of 6 months.Results: Patients presented at a mean
age of 69 years (range 44--86). Mean duration of symptoms was 40
weeks (range 1--300). Mean (SD) VA at baseline was 0.79 (0.39)
logMAR, improving to 0.51 (0.34) logMAR at 6 months (p = 0.009).
Mean number of letters on the ETDRS chart at baseline was 45.3
(19.0), improving to 60.6 (19.9) at 6 months (p = 0.003). Mean (SD)
retinal thickness at baseline was 474 (120) \textgreekmm, declining
to 316 (41) \textgreekmm at 6 months.Conclusion: Intravitreal
injection of 1.25 mg bevacizumb appears to be an effective
treatment option for branch retinal vein occlusion.