Distribution and Excretion of BisGMA in Guinea Pigs

Bisphenol-A-glycidyldimethacrylate (BisGMA) is used in many
resin-based dental materials. It was shown in vitro that BisGMA was
released into the adjacent biophase from such materials during the
first days after placement. In this study, the uptake,
distribution, and excretion of [14C]BisGMA applied via gastric and
intravenous administration (at dose levels well above those
encountered in dental care) were examined in vivo in guinea pigs to
test the hypothesis that BisGMA reaches cytotoxic levels in
mammalian tissues. [14C]BisGMA was taken up rapidly from the
stomach and intestine after gastric administration and was widely
distributed in the body following administration by each route.
Most [14C] was excreted within one day as 14CO2. The peak
equivalent BisGMA levels in guinea pig tissues examined were at
least 1000-fold less than known toxic levels. The peak urine level
in guinea pigs that received well in excess of the
body-weightadjusted dose expected in humans was also below known
toxic levels. The study therefore did not support the hypothesis.