Allergologische Diagnostik von Überempfindlichkeitsreaktionen auf Arzneimittel

Drug hypersensitivity reactions have to be tested to identify the
culprit substance. The history includes the general information and
specific data concerning used drugs, the classification and
circumstances of the reaction. Skin tests are performed in all
hypersensitivity reactions with allergic symptoms. Tests should be
done between four weeks and six months after clearance of the
symptoms by performing skin prick test, intradermal test, patch
test or photopatch test. Validated tests for the detection of
specific IgE antibodies in the serum are available for only few
drugs, especially betalactam antibiotics. Other laboratory tests,
e.g., the basophil activation test are done only in special cases.
Provocation tests are indicated, if the culprit drug cannot be
identified by the above mentioned tests. If possible, the
evaluation of provocation tests should rely on objective
parameters. The concluding assessment will be discussed with the
patient and will be documented in an allergy pass.