Fibrinogen and factor XIII A-subunit genotypes interactively influence C-reactive protein levels during inflammation

Fibrinogen is a target of autoimmune reactions in rheumatoid
arthritis (RA). Fibrin(ogen) derivatives are involved in
inflammatory processes and the generation of a stable fibrin
network is necessary for sufficient inflammation control. As the
density and stability of fibrin networks depend on complex
interactions between factor XIIIA (F13A) and fibrinogen genotypes,
the authors studied whether these genotypes were related to
C-reactive protein (CRP) levels during acute-phase reactions.