Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex

One of the most important hormones in the human stomach is the
peptide gastrin. It is mainly required for the regulation of
gastric pH but is also involved in growth and differentiation of
gastric epithelial cells. In Helicobacter pylori infected patients,
gastrin secretion can be upregulated by the pathogen, resulting in
hypergastrinaemia. H pylori induced hypergastrinaemia is described
as being a major risk factor for the development of gastric
adenocarcinoma.