The Complexity of Arterial Classical Monocyte Recruitment

Accumulation of classical monocytes is imperative for the
progression ofatherosclerosis. Hence, therapeutic interference with
mechanisms oflesional monocyte recruitment, the primary mechanism
controllingmacrophage accumulation, may allow for targeting
atheroprogression andits clinical complications. Here, we review
the important role ofclassical monocytes in atheroprogression as
well as their routes ofarterial recruitment. We specifically
highlight the role of celladhesion molecules as well as of
platelet-derived chemokines andneutrophil-borne alarmins.