Nuclear Segmentation, Condensation and Bilateral Symmetry in Polymorphonuclear Leukocytes Reflect Genomic Order and Favor Immunologic Function

Segmentation, condensation and bilateral symmetry of the nuclei
ofpolymorphonuclear leukocytes seem related to their
function.Segmentation of the nuclei into two or more lobes and
their condensationfacilitate their passage (diapedesis) through the
endothelial layer ofblood vessels to the extravasal space and
subsequent locomotion throughthe interstitial compartment of
different tissues. Bilateral symmetry ofthese nuclei along with
their association to the cytoskeletal fiberscontribute to their
efficiency in locomotion by alignment of the axis ofnuclear
symmetry to the axis of cellular polarity, which orients towardsthe
direction of locomotion in response to cytokines and other
stimuli.Observations of the cytogenetic facets of intranuclear
order supportthese assumptions.