Front Page Papers with Joe Lennerz

Welcome to the Caring and Sharing Advanced Oncology podcast. In
this episode, Uta Schmidt-Straßburger is joined again by Dr. Joe
Lennerz, a board-certified pathologist and the chief scientific
officer at BostonGene.





The discussion covers two notable papers from BostonGene
scientists, featured on the covers of Cancer Cell and
Gastroenterology. These papers delve into tumor sample profiling,
introducing new classification methods.





Starting with the Cancer Cell paper, Dr. Lennerz explained their
advanced immunoprofiling assay from blood, which uses
high-complexity techniques to provide a comprehensive "immune
system count" of over 300 markers. This approach identifies five
distinct immunotypes, aiding in predicting responses to
immunotherapy, particularly in cancers like head and neck
squamous cell carcinoma.





Next, the Gastroenterology paper focuses on a microenvironment
classification of pancreatic ductal adenocarcinoma (PDAC). By
analyzing transcriptomic data from over 1600 patients, the team
identified four microenvironment subtypes with significant
prognostic implications. These findings could lead to better
stratification and treatment approaches for this aggressive
cancer.





Dr. Lennerz emphasized the potential of these classifications in
clinical trials and personalized treatment plans, highlighting
the innovative strides in oncology research.





Tune in to learn more about these groundbreaking studies and
their impact on cancer treatment. If you enjoyed the episode,
please like and subscribe. Thank you!